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See also
Cross-reaction
Competitive binding
Isoindoline
Neuromuscular junction
Receptor-based autocrine signaling
Toxin receptor
Vascular endothelial growth factor receptor
References
External links
Biosynthetic Activation – Merck Index
Category:Chemical reactionsThe process of naturally forming bone is a complex process involving the interplay of cells and matrix proteins that regulate the equilibrium between matrix synthesis and degradation. To repair damaged or diseased tissues, cells can be recruited from surrounding tissues or organs and then induced to proliferate and differentiate in situ. Bone matrix is primarily composed of type I collagen and a proteoglycan (PG) termed "osteoid". Together, these macromolecules form a scaffold within which new bone is deposited.
Unfortunately, in many situations it is not possible to replace the tissue with natural bone. For example, it is not possible to form bone in an arthritic joint. In such cases it is necessary to provide a scaffold for the growth of new bone. However, it is not possible to use tissue of the host organism for these purposes. The host's cells may have formed undesirable chemical and/or physical interactions with the scaffold.
Thus, in situations where natural bone regeneration cannot occur, there is a need for a source of bone-like material which has similar physical and chemical properties to natural bone and/or which may be used as a scaffold to guide the growth of new bone.
A number of materials have been used as bone replacement materials, including c be359ba680
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